Studies on the Local Anesthetics II Local anesthetic action of 3-dialkylamino-2-hydroxypropyl phenylacetate, 3-dialkylamino-2-hydroxypropyl benzoate derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts.
Tertiary amines 3-(dialkylamino)-2-hydroxypropyl 4-[(alkoxycarbonyl)amino]benzoates and their quaternary ammonium salts were synthesized. The final step of synthesis of quaternary ammonium salts was carried out by microwave-assisted synthesis. Software-calculated data provided the background needed to compare fifteen new resulting compounds by their physicochemical properties. The acid dissocia...
متن کامل3-[(3-Hydroxypropyl)amino]-1-phenylbut-2-en-1-one
The title compound, C(13)H(17)NO(2), has an intra-molecular N-H⋯O hydrogen bond, forming a planar six-membered ring with a mean deviation of 0.015 (5) Å from the plane. This plane makes a dihedral angle of 7.19 (8)° with the adjacent phenyl ring. Through an inter-molecular O-H⋯O hydrogen bond, the mol-ecules with their 2(1) screw and b-translation equivalents form a helical chain running parall...
متن کاملNon anesthetic action of local anesthetics
Local anesthetics are not only used as drugs to block the sodium channel to provide analgesia and anti-arrhythmic action. The purpose of this review is to highlight the new indications and limitations of this class of drugs. Recent research has focused on the use of i.v. local anesthetics to improve bowel function after surgery or trauma, to protect the central nervous system, to find new clues...
متن کاملSynthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles
N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...
متن کاملsynthesis of n, n΄3, 4-dialkylamino-1, 2, 5-oxadiazoles
n, n΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of n, n΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚c. under similar conditions n, n΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and n, n΄-3, 4-di(isopropylamino)-1, 2, 5-oxadiazole (1e) were not obtained, but, n, n΄-3, 4-di(ethylamino)-1, 2, 5-oxadiazole (1g) was appeared with smal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Oral Biology
سال: 1980
ISSN: 0385-0137
DOI: 10.2330/joralbiosci1965.22.238